Gene information
Official symbol SERPINA1
Official full name serpin family A member 1
Gene type protein-coding gene
Chromosome14q32.13
Alias symbolAAT; A1A; PI1; alpha-1-antitrypsin; A1AT; alpha1AT
Previous symbolPI
Gene familySerpin peptidase inhibitors
Resources
Entrez Gene 5265
HGNC HGNC:8941
Ensembl ENSG00000197249
Vega OTTHUMG00000150355
UCSC uc010auy.3
GO terms: 37 records
GO Description Category LogP Number of genes Detail
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004867 serine-type endopeptidase inhibitor activity GO Molecular Functions -8.20238048 12 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030134 COPII-coated ER to Golgi transport vesicle GO Cellular Components -3.04449021 6 More
GO:0030135 coated vesicle GO Cellular Components -4.65185370 14 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:1904813 ficolin-1-rich granule lumen GO Cellular Components -6.12299383 11 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
.alpha.1-proteinase inhibitor human TTD view
igmesine TTD view
Related studies: 7 records
Molecular factor Omics type Application Objective MI type Reference
NM_000295.5:c.1096G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Listi F et al. Biogerontology. 2007
NM_000295.5:c.[710T>C;1096G>A] genomics acute myocardial infarction[diagnosis] acute myocardial infarction Listi F et al. Biogerontology. 2007
alpha-1-antitrypsin proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Krcmova J et al. Cas Lek Cesk. 1989
alpha-1-antitrypsin proteomics adverse events[prognosis (bad)] myocardial infarction Solod NN et al. Sov Med. 1989
alpha-1-antitrypsin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Gilutz H et al. Br Heart J. 1983
alpha-1-antitrypsin proteomics adverse events[prognosis (bad)] acute myocardial infarction Gilutz H et al. Br Heart J. 1983
alpha-1-antitrypsin proteomics myocardial infarction[diagnosis] myocardial infarction Nordestgaard BG et al. Clin Chem. 2010
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